After studying electrical engineering and information technology and completing his doctorate in 1992 at TUM, Prof. Diepold developed video compression systems and MPEG standards (MPEG-4, MPEG-A). In 2002 he accepted the Chair of Data Processing at TUM, where he served as Dean of Studies from 2005 to 2010.

Visiting professorships took him to Alberta, Canada and NICTA in Australia. Prof. Diepold is a member of CDTM’s supervisory board and was on the board of management of the cluster of excellence Cognition for Technical Systems (CoTeSys) from 2006 to 2014. From 2013 to 2015 he served as TUM's Senior Vice President for Diversity and Talent Management. The web video series “Technically Single”, which he initiated, aired nationwide in 2018.

Professor Diepold conducted research in the field of multimedia signal processing with a focus on the design of fast algorithms. Today he concentrates on machine learning, which entails developing moral machines as well as modeling and simulating affects for cognitive systems. He is also actively involved in entrepreneurship training for students from all departments at the Center for Digital Technology and Management (CDTM) and promotes entrepreneurship within his own department.

Prof. Dr. Klaus Diepold serves as a research fellow at fortiss where he supports the institute with his expertise in the field of electronics and computer science technology.